… of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial

C Loo, N Glozier, D Barton, BT Baune… - The British Journal of …, 2023 - cambridge.org
… with major depression do not remit even after four trials of … This was the largest randomised
controlled trial of racemic keta… superior antidepressant efficacy to an active control drug, …

Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression

CA Farmer, JR Gilbert, R Moaddel, J George… - …, 2020 - nature.com
… ), a racemic mixture comprising (S)- and (R)-ketamine, produces antidepressant … with major
depressive disorder (MDD) [1], bipolar depression [2, 3], and treatment-resistant depression (…

… and anti-suicidal effects of ketamine in treatment-resistant depression associated with psychiatric and personality comorbidities: a double-blind randomized trial

GK Ahmed, YM Elserogy, GMA Elfadl… - Journal of affective …, 2023 - Elsevier
ketamine on SI have been obtained mainly from secondary analyses of randomized controlled
trials investigating the antidepressant … –36 does not indicate clinical depression in men; 37…

[HTML][HTML] … double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

PR Shiroma, P Thuras, J Wels, CS Albott… - Translational …, 2020 - nature.com
… Repeated ketamine showed greater antidepressant efficacy … in a randomized controlled
trial in treatment-resistant major … among subjects with treatment-resistant major depression. …

[HTML][HTML] Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

J Kopelman, TA Keller, B Panny, A Griffo… - Translational …, 2023 - nature.com
Major depressive disorder is the leading cause of disability adjusted life … ketamine, a
dissociative anesthetic, has rapid and robust antidepressant effects, including in treatment-resistant

Cognitive behavioral therapy to sustain the antidepressant effects of ketamine in treatment-resistant depression: a randomized clinical trial

ST Wilkinson, TG Rhee, J Joormann… - Psychotherapy and …, 2021 - karger.com
randomized trial to examine the feasibility and efficacy of cognitive behavioral therapy (CBT)
following intravenous ketamine in treatment-resistant depression (… severe major depressive

[HTML][HTML] Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

M Fava, MP Freeman, M Flynn, H Judge… - Molecular …, 2020 - nature.com
… -controlled study of the acute efficacy of IV ketamine or … adequate ADTs during the current
major depressive episode (TRD). … of antidepressant efficacy of all doses of ketamine vs. active …

Single, repeated, and maintenance ketamine infusions for treatment-resistant depression: a randomized controlled trial

JL Phillips, S Norris, J Talbot, M Birmingham… - Focus, 2020 - Am Psychiatric Assoc
Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site
randomized controlled trial. Am J … A randomized trial of an N-methyl-d-aspartate antagonist in …

… dissociation as a predictor of induced dissociation by ketamine or esketamine in treatment-resistant depression: secondary analysis from a randomized controlled trial

RP Mello, MVF Echegaray, AP Jesus-Nunes… - Journal of Psychiatric …, 2021 - Elsevier
Clinical predictors of antidepressant efficacy, such as induced dissociation, may have an
advantage over other predictors, such as some imaging tests, which can be expensive and are …

Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: a randomized, double-blind, non-inferiority …

FS Correia-Melo, GC Leal, F Vieira… - Journal of affective …, 2020 - Elsevier
… -acting antidepressants such as ketamine and esketamine. … kg of ketamine in promoting the
remission of major depression … with previous placebo, controlled trials comparing results 24 h …